名詞 vicissitude:

1. a variation in circumstances or fortune at different times in your life or in the development of something
2. mutability in life or nature (especially successive alternation from one condition to another)

1. He was battling against the vicissitudes of life.
   他在每況愈下的生活中奮斗。

vi.cis.si.tude

n.（名詞）

A change or variation.
變化或變動
The quality of being changeable; mutability.
變化無常：作為可變化的性質(zhì)；變動
Often vicissitudes One of the sudden or unexpected changes or shifts often encountered in one`s life, activities, or surroundings.See Synonyms at difficulty
常作 vicissitudes 變遷，盛衰：在人的一生中、活動中或者周圍環(huán)境中會碰到的忽然或者想不到的變化或變遷參見 difficulty

來源：
Latin vicissitôdô
拉丁語 vicissitôdô
from vicissim [in turn]
源自 vicissim [按順序]
probably from vicôs
可能源自 vicôs
pl. of *vix [change] * see weik- 2
*vix的復(fù)數(shù) [變化] *參見 weik- 2